The compound SCH-79797 destroys even the strongest bacteria and does not develop resistance to it.
Scientists from Princeton University in the United States have discovered a compound that defeats the most antibiotic-resistant bacteria. The results of the study were published in the journal Cell on June 3.
Compound SCH-79797, which has a double action, can simultaneously pierce the walls of bacteria and destroy folic acid in their cells. At the same time, bacteria do not develop drug resistance to it.
Note that over the past thirty years, not a single new drug has appeared that can kill gram-negative bacteria, which, unlike gram-positive ones, are protected by an outer layer that protects them from most antibiotics.
As Professor Zemer Gitai emphasized, SCH-79797 simultaneously attacks from the inside and outside, and can destroy even the most powerful opponents – from Escherichia coli E. coli to staphylococcus and gonococcus resistant to all known antibiotics.
“This is the first antibiotic that acts against gram-positive and gram-negative bacteria without resistance. We hope that in the future this will lead to the emergence of new types of antibiotics,” said Gitai.
He indicated that the compound was called “irresistin.”
The main problem with antibiotics is that bacteria quickly develop resistance to them, but studies have shown that no pathogen can withstand SCH-79797.
So, scientists for 25 days again and again exposed the pathogens to the drug, and even received from the World Health Organization repositories the most stable strain of gonococcus Neisseria gonorrhoeae, which is in the top 5 most difficult to treat.