Researchers at McGill University in Canada have shown that vitamin D is probably useless for preventing COVID-19.
The specialists conducted a Mendelian randomization to assess the causal relationship between vitamin D levels, susceptibility to coronavirus, and the severity of COVID-19 symptoms. Blood levels of 25-hydroxyvitamin D (one form of vitamin D) are known to be dependent on certain genetic variants (polymorphisms), so if vitamin D does affect the incidence of COVID-19, the presence of polymorphisms should also have an effect on risk of infection and development of severe infection.
A full genome-wide association search to determine the association between genomic variants and vitamin D levels covered biomedical data from 443,734 individuals. To examine the association between genotype and susceptibility to COVID-19, the authors analyzed the genetic variants of 4134 people with COVID-19 and 1,284,876 people without COVID-19 from 11 countries. It turned out that increased levels of 25-hydroxyvitamin D had no significant association with susceptibility to COVID-19.
The results indicate that increasing circulating vitamin D levels with supplementation may not improve COVID-19-related outcomes. This confirms that vitamin D levels are related to extrinsic factors such as age and the presence of chronic disease, which also affect susceptibility to coronavirus.
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